ORCHARD THERAPEUTICS PLC

(Name of Issuer)

68570P101

(CUSIP Number)

☐	Rule 13d-1(b)
☐	Rule 13d-1(c)
☒	Rule 13d-1(d)

CUSIP No. 68570P101	13G	Page 2 of 6

Item 1.
	(a)	Name of Issuer: Orchard Therapeutics plc
	(b)	Address of Issuer’s Principal Executive Offices: 108 Cannon Street, London EC4N 6EU United Kingdom
Item 2.
	(a)	Name of Person Filing: GlaxoSmithKline plc
	(b)	Address of Principal Business Office or, if none, Residence: 980 Great West Road, Brentford, Middlesex TW8 9GS, United Kingdom
	(c)	Citizenship: England and Wales
	(d)	Title of Class of Securities: Ordinary Shares, par value £0.10
	(e)	CUSIP Number: 68570P101
Item 3.	If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
	(a)	☐	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).
	(b)	☐	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
	(c)	☐	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).
	(d)	☐	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).
	(e)	☐	An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);
	(f)	☐	An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);
	(g)	☐	A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G);
	(h)	☐	A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
	(i)	☐	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
	(j)	☐	A non‑U.S. institution in accordance with §240.13d‑1(b)(ii)(J);
	(k)	☐	Group, in accordance with §240.13d-1(b)(1)(ii)(K).

If filing as a non‑U.S. institution in accordance with §240.13d‑1(b)(1)(ii)(J), please specify the type of institution: An employee benefit plan subject to the provisions of the Pension Benefits Act of Ontario and regulations thereunder.

Item 4.	Ownership
Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.
	(a)	Amount beneficially owned: See response to Item 9 on the cover page.
	(b)	Percent of class:  See response to Item 11 on the cover page..
	(c)	Number of shares as to which the person has: See response to Item 9 on the cover page.
		(i)	Sole power to vote or to direct the vote    See response to Item 5 on the cover page.
		(ii)	Shared power to vote or to direct the vote     See response to Item 6 on the cover page.
		(iii)	Sole power to dispose or to direct the disposition of    See response to Item 7 on the cover page.
		(iv)	Shared power to dispose or to direct the disposition of    See response to Item 8 on the cover page.
Item 5.	Ownership of Five Percent or Less of a Class
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following  ☐
Item 6.	Ownership of More than Five Percent on Behalf of Another Person
Glaxo Group Limited*                                    12,455,252                                        14.5%   *Shares are held of record by Glaxo Group Limited, an indirect, wholly-owned subsidiary of the Reporting Person.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person
See response to Item 6.
Item 8.	Identification and Classification of Members of the Group
Not applicable.

Item 9.	Notice of Dissolution of Group
Not applicable.
Item 10.	Certification
Not applicable.

GLAXOSMITHKLINE PLC
	By:	/s/ Victoria A. Whyte
		Name: Victoria A. Whyte
		Title: Authorized Signatory